自律:在医患关系中的定位

医疗行为的特殊性，决定了医患双方在医学信息方面的不对称性和医者拥有一定的自由裁量权，因此，医者作为医疗服务的主体，如何增强自律意识，直接关系到诚信的树立及和谐的互动式医患关系的建立和发展。     

17β-雌二醇对子宫内膜异位症患者在位子宫内膜间质细胞β-catenin mRNA和蛋白表达的影响

目的研究17β-雌二醇(17β-E2)对子宫内膜异位症(内异症)患者在位子宫内膜间质细胞β-catenin mRNA和蛋白表达的影响,探讨Wnt/β-catenin信号通路在介导雌激素促进内异症发生发展的作用。方法体外分离培养内异症患者在位子宫内膜间质细胞。用不同浓度17β-E2处理子宫内膜间质细胞48 h;此后选用10-10mol/L 17β-E2处理子宫内膜间质细胞12、24和48 h,逆转录聚合酶链反应(RT-PCR)和免疫印迹法(Western blotting)检测17β-E2处理前后子宫内膜间质细胞β-catenin mRNA和蛋白的表达水平。同法分析雌激素受体拮抗剂ICI182,780(10-6mol/L)对17β-E2促进β-catenin mRNA和蛋白表达的影响。免疫组织化学染色观察17β-E2作用后β-catenin在子宫内膜间质细胞中的定位。结果17β-E2能明显促进内异症患者在位子宫内膜间质细胞β-catenin mRNA和蛋白的表达,并呈剂量和时间依赖性,于10-10mol/L作用48 h最明显。雌激素受体拮抗剂ICI182,780能明显抑制17β-E2对子宫内膜间质细胞β-catenin mRNA和蛋白的表达。免疫组织化学染色发现17β-E2能促进β-catenin在子宫内膜间质细胞核内的表达。结论雌激素可能通过激活Wnt/β-catenin信号通路促进内异症在位子宫内膜的异位种植。     

医学外文图书采访工作改革

分析了医学外文图书采访工作存在的问题,提出了改革医学外文图书采访工作的若干建议.     

The Application of Number Needed to Treat (NNT) to Clinical Problems in Radiotherapy

The goals of this report are: 1) to review the number needed to treat (NNT) concept, which, although well established in many sectors of medicine, is still relatively new to the radiotherapy community; 2) to discuss several clinical radiotherapy examples illustrating the inherent advantages of the NNT approach; and 3) to discuss potential future roles of the NNT concept within radiotherapy.     

Mifepristone in Italy: the case of a drug trapped between ethics and clinical practice

In Italy mifepristone is not yet marketed. Gynaecologists in our hospital asked to use this medication as a less traumatic method for voluntary abortions. We followed the standard procedure defined by the Italian Health Ministry (IMH) for purchasing drugs from abroad but encountered several unexpected barriers. Starting from this case, this paper is aimed at identifying these barriers which we found to be not only professional, but also ethical, religious and moral.     

Report from the 1st Japanese Urological Association-Japanese Society of Medical Oncology joint conference, 2006: ''A step towards better collaboration between urologists and medical oncologists''

The 1st Japanese Urological Association-Japanese Society of Medical Oncology Joint Conference, titled 'A step towards better collaboration between urologists and medical oncologists', was held to coincide with the 44th Meeting of the Japan Society of Clinical Oncology, Tokyo, in October 2006. The main theme of the conference addressed the need for a subspecialty of medical oncologist within urology to keep abreast of advances in medical oncology. Urologists should become more involved in the postoperative management of urologic cancer. Consensus on the optimal way to move forward in the treatment of urological cancer is needed. The conference featured eight lectures surveying the present status of uro-oncology in Europe, the USA, Korea, Singapore, and Japan; the relationship between surgical oncologists and medical oncologists; global trends and international clinical trials in uro-oncology; and the future of urologic oncology. These were followed by a general discussion titled 'Achieving better collaboration between the surgical oncologist and the medical oncologist.' This report presents a roundup of the 1st Japanese Urological Association-Japanese Society of Medical Oncology Joint Conference.     

小血管套叠粘接吻合法在血液透析者中建立动静脉内瘘的应用

慢性肾病患者常需要建立动静脉内瘘进行透析，常规间断缝合法吻合动静脉难度大、耗时长。为了缩短吻合时间，提高远期通畅率，进行了套叠粘接吻合法建立动静脉内瘘的实验研究，并将这一方法应用于透析患者建立动静脉内瘘的血管吻合。将动脉端套入静脉端，只需吻合两针，用医用胶封闭吻合口。经８个月观察，通畅率达１００％，血流量均超过３００ｍｌ／ｍｉｎ。达到了透析需要。     

医科职业中专生与医科本科生孤独,抑郁,自尊状况的比较研究

目的探讨医科职业高中生与医科本科生的心理健康状况的差异。方法采用ＵＣＬＡ、自尊量表、抑郁量表、感情与社会孤独量表及自编情况调查表对３５０名在校职业高中医士班、医学院本科学生进行评定。结果职业高中学生的孤独及抑郁量表得分高于医学院学生，自尊量表得分低于医学院学生。职高组轻度和中度抑郁占４２．６２％，大学组轻度和中度抑郁占２０％。结论职业高中学生心理健康水平低于医学本科生     

五所医院特需医疗服务状况调查

通过对上海医科大学附属华山医院、协和医院、北京同仁医院、中山医科大学附属第一医院、浙江医科大学附属第二医院开展的特需医疗服务情况的调查，论述了五所医院的具体做法，在对调查结果进行分析的基础上，就特需医疗服务的管理提出了建议。     

高氧医用液在高位硬膜外麻醉中低张性缺氧的应用

目的　研究高氧医用液在高位硬膜外麻醉中治疗和预防低张性缺氧的效果和安全性。方法　将10 0例胸壁手术患者随机分成高氧液治疗组 (A组 )和同等量细胞外液治疗组 (B组 ) ,均在高位硬膜外麻醉下完成胸壁手术 ,入室后输液速度第 1小时为 10ml (Kg·h) ,以后 6ml (Kg·h) ;A组输入高氧液 ,B组输入林格氏液 ;两组患者出现SPO2 <95 %时面罩给氧 ,氧流量 3～ 5L min ;两组于麻醉前和麻醉后 30、6 0、90min及术毕麻醉平面消失后 5个时点各抽取动脉血 1ml进行血气分析 ,同时观察生命体征和术中不良反应。结果　两组各时点血气结果各项指标均在正常范围内波动 ,组间、组内比较均无显著性差异 (P >0 .0 5 ) ,术中A组无需面罩给氧治疗 ,B组全部需面罩给氧治疗 ;A组生命体征各指标在各时点无显著性差异 (P >0 .0 5 ) ,B组在麻醉后初期呼吸频率增快 ,较麻醉前和A组比较均有显著性差异 (P <0 .0 5 ) ;术中两组患者均无寒战、烦躁、头痛、过敏、气栓等不良反应发生。结论　高氧医用液为术中高位硬膜外麻醉所致的缺氧提供了全新的供氧方法 ,且有使用方便、安全性强、疗效确切等优点。